Computational Fluid Dynamics Simulations of Inhaled Nano-and Micro-Particle Deposition in the Rhesus Monkey Nasal Passages

Abstract

Anatomically accurate computational fluid dynamics (CFD) models of the nasal passages of an infant (6 months old, 1.3 kg) and adult (7 years old, 11.9 kg) rhesus monkey were used to predict deposition of inhaled nano- and micro-particles. Steady-state, inspiratory airflow simulations were conducted in each model at flow rates equal to 100%, 200%, and 300% of the estimated minute volume for resting breathing. Particle transport and deposition simulations were conducted using the Lagrangian method to track the motion of individual particles that were passively released from the nostrils. Semi-empirical curves for nasal deposition were developed based on the simulation data for nano- and micro-particle deposition to allow for simplified calculations of age-based nasal deposition in the rhesus monkey nasal passages that can be implemented into lung dosimetry models.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2016
Accession Number
AD1024081

Entities

People

  • Bahman Asgharian
  • Gene E. Mcclellan
  • Jeffry D. Schroeter
  • Owen T. Price

Organizations

  • Applied Research Associates (United States)

Tags

DTIC Thesaurus Topics

  • Brain
  • Central Nervous System
  • Computational Fluid Dynamics
  • Computer Simulations
  • Department Of Defense
  • Equations
  • Fluid Dynamics
  • Magnetic Resonance
  • Measurement
  • Nanoparticles
  • Nervous System
  • Nose
  • Numerical Analysis
  • Particle Size
  • Particles
  • Three Dimensional
  • Turbulent Mixing

Readers

  • Computational Fluid Dynamics (CFD)
  • Toxicology/Environmental Toxicology