Stress and PTSD Mechanisms as Targets for Pharmacotherapy of Alcohol Abuse, Addiction and Relapse

Abstract

We have demonstrated that (1) alcohol-nave rats exhibiting high acoustic startle response which is sequent associated with increased anxiety-like behavior) develop increased subsequent alcohol intake and preference which are highly correlated with acoustic startle amplitude determined before the initial access to alcohol, providing a prospective index of vulnerability to developing alcohol abuse, as well as insights into mechanism.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2016
Accession Number
AD1024106

Entities

People

  • Dennis Rasmussen

Organizations

  • Seattle Institute for Biomedical and Clinical Research

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acquisition
  • Addiction
  • Alcoholism
  • Amino Acids
  • Amplitude
  • Anxiety Disorders
  • Brain
  • Brain Injuries
  • Chemistry
  • Diseases And Disorders
  • Health Care
  • Health Services
  • Intensity
  • Medical Personnel
  • Psychiatry
  • Traumatic Stress Disorder

Fields of Study

  • Medicine

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