Targeting TMPRSS2 ERG in Prostate Cancer

Abstract

TMPRSS2-ERG is an oncogenic translocation present in approximately half of all prostate cancers. Despite being an attractive therapeutic target, transcription factors have historically been difficult target pharmacologically. Furthermore, the exact of ERG in mediating tumorigenesis is unknown making it difficult to develop physiologically relevant assays to measure its activity.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2016
Accession Number
AD1024135

Entities

People

  • David Takeda

Organizations

  • Dana–Farber Cancer Institute

Tags

DTIC Thesaurus Topics

  • Cell Line
  • Cells
  • Chemistry
  • Data Analysis
  • Gene Expression
  • Genes
  • Genetics
  • Indicator Dyes
  • Inhibition
  • Inhibitors
  • Molecules
  • Neoplasms
  • Prostate Cancer
  • Small Molecules
  • Surface Plasmon Resonance
  • Surface Plasmons
  • Transcription Factors

Fields of Study

  • Medicine

Readers

  • Mathematics or Statistics
  • Oncology (Cancer Research).
  • Prostate Cancer Biology.