A Novel Approach to Assay DNA Methylation in Prostate Cancer

Abstract

Previous studies of DNA methylation at 5-position of cytosine (5mC) have led to the discovery of useful methylation biomarkers for prostate cancer diagnosis and prognosis, some of which are being developed into clinical tests. However, several seminal studies have recently reported that DNA methylation (5mC) can be de-methylated by the TET proteins resulting in 5-hydroxylmethylation (5hmC), which plays functional roles distinct from 5mC but yet is indistinguishable from 5mC by a majority of existing methylation assays.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2016
Accession Number
AD1024725

Entities

People

  • Jidan Yu

Organizations

  • Northwestern University

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Enzyme Inhibitors
  • Gene Expression
  • Genetics
  • Medical Personnel
  • Neoplasms
  • Oncology
  • Prostate Cancer
  • Proteins
  • Stem Cells

Fields of Study

  • Biology
  • Chemistry

Readers

  • Molecular Genetics
  • Oncology and Biomarker-Based Cancer Detection.
  • Positioning, Navigation, and Timing (PNT) Technology.