YY1 Control of AID-Dependent Lymphomagenesis

Abstract

We hypothesized that YY1 levels control AID nuclear accumulation, AID mutation rates, and subsequent AID-mediated B cell lymphomagenesis. We tested this hypothesis by exploring the impact of YY1 overexpression, ordeletion, in mouse lines that spontaneously develop AID-dependent B cell lymphoma. Our results suggest that overexpression of YY1 leads to higher mortality.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2016
Accession Number
AD1024757

Entities

People

  • Michael Atchison

Organizations

  • University of Pennsylvania

Tags

DTIC Thesaurus Topics

  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Chromosomes
  • Genetics
  • Health Services
  • Lymphatic System
  • Lymphocytes
  • Medical Personnel
  • Proteins
  • Stem Cells

Fields of Study

  • Biology

Readers

  • Circadian Sleep-Wake Regulation and Chronobiology
  • Immunology
  • Molecular Biology and Genetics