Utilization of ICU Data to Improve 30 and 60 Day Mortality Models

Abstract

This report presents the use of available ICU data to extend the capabilities of 30 and 60-day mortality models in the Health Effects from Nuclear and Radiological Environments (HENRE) software. These models relate levels of molecular and cellular biomarkers currently modeled in HENRE to mortality using data from the medical literature. A small intestine injury model predicts the probability of 30-day mortality after radiation and burn combined injuries using the biomarker citrulline, and a platelet reduction model predicts the probability of 60-day mortality after burn. These models have been developed to predict mortality of casualties with access to standard medical care. A review of the literature on the use of the neutrophil to lymphocyte ratio (NLR) as a biomarker of inflammation and mortality is presented. The NLR may be used in future work to further extend the capabilities of the mortality models in HENRE.

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Document Details

Document Type
Technical Report
Publication Date
Jan 06, 2017
Accession Number
AD1025201

Entities

People

  • Dave Crary
  • Jacob Bellman
  • Jason Pirone
  • Stephen Beaulieu

Organizations

  • Applied Research Associates (United States)

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Adaptive Immunity
  • Blood
  • Burns
  • Cardiovascular System
  • Cells
  • Disease Attributes
  • Health Services
  • Hemorrhage
  • Intestines
  • Leukocytes
  • Lymphocytes
  • Mathematical Models
  • Patient Care
  • Radiation Injuries
  • Therapy
  • Wound Infections
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Computational Modeling and Simulation
  • Immunology and Pathology
  • Nuclear and Radiation Engineering.