Optogenetic Stimulation of Peripheral Vagus Nerves Using Flexible OLED Display Technology to Treat Chronic Inflammatory Disease and Mental Health Disorders

Abstract

This work explored the viability of a biophotonic alternative to conventional prescription-drug-based treatments for inflammatory disease and mental health disorders using a non-invasive drug-free optogenetics-based therapy that treats patients by optically stimulating afferent branches of the auricular vagus transcutaneously via the outer ear using a high-resolution, addressable array of organic light emitting diodes (OLEDs) manufactured on a flexible plastic substrate. Preliminary analysis and optical measurements indicate that our 620 nm flexible red OLED display technology is bright enough to induce therapeutic optical stimulation in optogenetically modified neural tissue.

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Document Details

Document Type
Technical Report
Publication Date
Mar 31, 2016
Accession Number
AD1025262

Entities

People

  • Ankur Shah
  • Barry O'brien
  • David R. Allee
  • Dixie E. Kullman
  • Jennifer B. Christen
  • Jitendran Muthuswamy
  • Joseph T. Smith
  • Yong-kyun Lee

Organizations

  • Arizona State University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anxiety Disorders
  • Bandages
  • Diseases And Disorders
  • Electronics
  • Films
  • Flexible Electronics
  • Light Sources
  • Mass Production
  • Medical Personnel
  • Oled Display Systems
  • Organic Light Emitting Diodes
  • Side Effects
  • Thin Films
  • Transducers
  • Traumatic Stress Disorder
  • Two Dimensional
  • Vagus Nerve

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Integrated Circuit Design and Technology.
  • Neuroscience