A Phase I Trial of an Immune Checkpoint Inhibitor Plus Stereotactic Ablative Radiotherapy in Patients with Inoperable Stage I Non-Small Cell Lung Cancer
Abstract
This clinical trial is the first to evaluate the synergy between radiation, a well-known immune modulator, with the novel immune checkpoint inhibitor MPDL3280A (atezolizumab) in early stage inoperable non-small cell lung cancer. The trial is comprised of a traditional 3 + 3 phase I design followed by a dose expansion. We have enrolled 3 patients into dose level 1. Two patients have completed the entire treatment plan and 1 patient is in the 9-week dose limiting time period. The regimen has been well tolerated with no dose limiting toxicities observed in the first two patients. One patient had a partial response and the other patient has stable disease. Interestingly patient #1 had tumor shrinkage after two cycles of low dose MPDL3280A without the radiation. The trial continues as planned.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2016
- Accession Number
- AD1025955
Entities
People
- Arta Monjazeb
- James Edward Mitchell
- Karen Kelly
- Megan Daly
Organizations
- University of California, Davis