Differential Splicing of Oncogenes and Tumor Suppressor Genes in African- and Caucasian-American Populations: Contributing Factor in Prostate Cancer Disparities

Abstract

There are striking population/race disparities in prostate cancer (PCa) risk and survival outcome borne out of current health statistics data. This is particularly evident between African Americans(AA) and their European American (EA) counterparts. Epidemiologic studies have shown that higher mortality and recurrence rates for prostate cancer are still evident in AA men even after adjustment for socioeconomic status, environmental factors and health care access. Thus, it is likely that intrinsic biological differences account for some of the cancer disparities. Our overarching hypothesis is that the biological component of prostate cancer health disparities is due, in part, to population-dependent differential splicing of oncogenes and tumor suppressor genes in cancer specimens. The application of genomic approaches has identified splice variants in AA specimens, but absent in EA specimens, encoding more aggressive oncogenic proteins, thereby producing a more cancerous phenotype.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
AD1025960

Entities

People

  • Bi-Dar Wang
  • Jacqueline Olender
  • Norman H. Lee

Organizations

  • George Washington University

Tags

DTIC Thesaurus Topics

  • African Americans
  • Androgen Receptors
  • Cell Physiological Processes
  • Chemistry
  • Ethnic Groups
  • Genetics
  • Health
  • Health Care
  • Health Services
  • Medical Personnel
  • Minority Groups
  • Molecules
  • Neoplasms
  • Prostate Cancer
  • Proteins
  • Small Molecules
  • Statistical Analysis

Fields of Study

  • Biology

Readers

  • Aviation Safety Risk Assessment.
  • Molecular Genetics
  • Prostate Cancer Biology.