Diagnosis of Late Stage, Early Onset, Small Fiber Polyneuropathy

Abstract

Our prior award generated evidence that some syndromes involving unexplained chronic multisymptom illness (CMI) and chronic widespread pain (CWP), including Gulf War Illness (GWI), may involve small-fiber polyneuropathy (SFPN). Objective diagnostic measures suggest that some veterans with GWI may have longstanding, persistent early-onset SFPN. We are developing and evaluating generally applicable tools that can better screen and test Veterans with GWI for such long-standing, early-onset SFPN. These include simple screening tools such as targeted questionnaires and detection of abnormal sweating, pupil size and reactivity. Once diagnosed, we plan to develop and apply DNA sequencing panels to identify polymorphisms that may convey risk for developing SFPN. This project, which expands on our previous findings, is in collaboration with the Veterans Biomedical Research Institute at the East Orange NJ Veterans Administration Hospital. This report covers first year progress.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2016
Accession Number
AD1025964

Entities

People

  • Anne L. Oaklander
  • Max M. Klein

Organizations

  • Massachusetts General Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Department Of Defense
  • Enlisted Personnel
  • Field Tests
  • Health
  • Health Services
  • Hospitals
  • Medical Personnel
  • Neuromuscular Diseases
  • Pain
  • Persian Gulf Syndrome
  • Pilot Studies
  • Professional Development
  • Public Health
  • Questionnaires
  • Reactivities
  • Sweating

Fields of Study

  • Medicine

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • STEM Education

Technology Areas

  • Biotechnology