A Pilot Study of Peritoneal Perfusion with a Novel Hemoglobin Based Oxygen Carrier in Swine (Sus scrofa)
Abstract
Extracorporeal membrane oxygenation (ECMO) has been used to treat the most severe cases of acute respiratory distress syndrome. However, this method has a high rate of complications, obliges systemic anticoagulation, and requires a significant level of logistics support as well as expertise. In light of these limitations, ECMO may not be an option in future conflicts with projected delayed evacuation times. We propose the concept of using the peritoneum for gas exchange and lung replacement. Ten Yorkshire-cross swine were anesthetized, mechanically ventilated, instrumented, and laparotomized. Inflow and outflow tubing were be placed in the abdomen, and connected to a heart-lung bypass circuit, and the abdomen closed. Animals were then randomized to peritoneal perfusion with either a novel bovine hemoglobin-based oxygen carrier or control (Lactated Ringers). After flow was established, the endotracheal tube was clamped, ceasing gas exchange in the lung. Arterial blood gases and time to death were then recorded. No differences were observed between treatment and control animals in terms of C02, 02 and time to death. Peritoneal gas exchange did not improve oxygenation, ventilation or time to death in this severe model of lung injury.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 12, 2016
- Accession Number
- AD1027316
Entities
People
- Ian J Stewart
Organizations
- David Grant USAF Medical Center