A Review of Analysis of Karyographs of the Human cell in Mitosis
Abstract
Since the publication of the first clear human karyograph by Tjio and Levan [13], much research, both theoretical and experimental, investigating the behavior of the chromosomes in the human cell during mitosis, has been carried out. Encouraged by L. S. Penrose and using karyographs made by him and by scientists working under him at the Galton Laboratory and, more recently, atthe Kennedy-Galton Centre for Mental Retardation Research, Harperbury, we have carried out an intensive statistical study of the positions of the chromosomes as indicated by their centromeres. A typical karyograph is illustrated in figure 1. It is the purpose of this present paper to present this study as a connected whole--it has previously been reported piecemeal as results were obtained-and to give such further work as has been done. Further, since such tests as we have devised may all be considered as variants of randomization tests in the plane, we advance here a way in which the randomization set might be weighted (or distorted), which leads to an approximate power function for the tests.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1967
- Accession Number
- AD1027565
Entities
People
- Dallin Barton
- Evelyn Fix
- F. David
- Maxine Merrington
Organizations
- University of California, Berkeley