Problem of Single Cell Versus Multicell Origin of a Tumor
Abstract
Cell markers have been used to study the cell population which gives rise to tumors. These traits are presumed to be transmitted to daughter cells and so set apart a cell or group of cells from surrounding cells of like type. Chromosome markers have been used to study experimentally induced and naturally occurring tumors [1], [8]. Such markers are usually considered chance findings, primarily serving to follow the growth of a particular cell line. The chromosomal variant itself may also be involved in tumor formation as strongly suggested by finding a consistently abnormal chromosome, the Philadelphia chromosome, in the leukocytes of individuals with chronic myelogenous leukemia [14]. Antigenic specificity of cells has also been employed to differentiate otherwise similar cells within a tumor [10], [16].
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1967
- Accession Number
- AD1027636
Entities
People
- David Linder
- Stanley M. Gartler
Organizations
- University of Washington