Role of Snf5 Mutations in Schwannomatosis Pain

Abstract

The overarching goal of this proposal is to test the hypothesis that Snf5 gene (also calledSMARCB1) mutations that occur in schwannomatosis patients contribute to the unique, untreatable pain experienced by these patients. During the first year of this project, we found that mice with Schwann cell-targeted Snf5 mutations demonstrated increased TRPV1 and CGRP expression, two factors linked to pain phenotype, expression in both large and small diameter sensory neurons and were typically co-expressed by these cells. We have also completed a proteomic screen of Snf5-mutant Schwann cell conditioned medium and identified several factors that may contribute to schwannomatosis pain phenotypes.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2016
Accession Number
AD1028268

Entities

People

  • Larry S Sherman

Organizations

  • Oregon Health & Science University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Culture Media
  • Culture Techniques
  • Department Of Defense
  • Diameters
  • Electronic Mail
  • Genes
  • Genetic Phenomena
  • Genetics
  • Medical Personnel
  • Multiple Sclerosis
  • Mutations
  • Nervous System
  • Neuroglia
  • Pain
  • Peripheral Nervous System
  • Phenotypes

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Neurotrauma and Rehabilitation Medicine.
  • Ocean-Atmosphere Mesoscale Modeling, Data Assimilation, and Flux Boundary Layers

Technology Areas

  • Biotechnology