Identification of Prostate Cancer-Specific Circular RNAs

Abstract

The major goal of this application is to determine whether newly identified circular RNAs can serve as novel biomarkers for prostate cancer diagnosis and prognosis. There are three specific aims. First, we will determine whether prostate cancer cells display different patterns of circular RNAs from those of normal tissue. Then, we will determine whether differential expression of circular RNAs can also be detected in cell culture models because we can easily manipulate the levels of circular RNAs in cell culture so that we are able to study their functions. Finally, we will determine whether circular RNAs are differentially expressed in blood/serum samples from healthy individuals and prostate cancer patients.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2016
Accession Number
AD1028277

Entities

People

  • Yin-Yuan Mo

Organizations

  • University of Mississippi Medical Center

Tags

DTIC Thesaurus Topics

  • Biological Markers
  • Biomedical Research
  • Breast Cancer
  • Culture Techniques
  • Department Of Defense
  • Diseases And Disorders
  • Electronic Mail
  • Identification
  • Information Operations
  • Neoplasms
  • Pcr Testing
  • Prostate
  • Prostate Cancer
  • Sequences
  • Tissues

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Oncology
  • Prostate Cancer Biology.