Targeting Sulfotransferase (SULT) 2B1b as a Regulator of Cholesterol Metabolism in Prostate Cancer

Abstract

Abundant epidemiological and experimental evidence establishes alterations in cholesterol metabolism as a key driver of prostate cancer (PCa) aggressiveness. Our preliminary data shows cholesterol sulfotransferase (SULT) 2B1b, a global regulator of cholesterol metabolism, is overexpressed in human prostate neoplasia and PCa cell lines and that genetic knock down suppresses LNCaP growth and diminishes androgen receptor (AR) activity. It is hypothesized that SULT2B1b modulates PCa growth and phenotype via alterations in cholesterol metabolism. If validated, the studies will form the foundation for novel therapeutic intervention.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
AD1028428

Entities

People

  • Timothy L Ratliff

Organizations

  • Purdue University

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Androgens
  • Apoptosis
  • Biomedical Research
  • Cell Line
  • Cell Physiological Processes
  • Culture Techniques
  • Diseases And Disorders
  • Inhibition
  • Inhibitors
  • Lead Compounds
  • Metabolism
  • Molecules
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Small Molecules

Readers

  • Prostate Cancer Biology.

Technology Areas

  • Biotechnology