Temporal Changes in FLT3 ITD Regulation of Stem Cell Self Renewal and Leukemogenesis

Abstract

My goal is to understand how mechanisms that regulate normal hematopoietic development can also influence the mutation spectra of pediatric and adult acute myeloid leukemia (AML). Genetic differences between pediatric and adult AML may underlie differences in outcomes and necessitate different treatment strategies, yet we have few insights into why these differences occur. To address this problem, we are testing whether one mutation, FLT3-ITD, differentially regulates fetal and adult progenitors.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2016
Accession Number
AD1028492

Entities

People

  • Jeffrey A Magee

Organizations

  • University of Washington

Tags

DTIC Thesaurus Topics

  • Blood
  • Bone Marrow Cells
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Genetics
  • Health Services
  • Lymphatic Diseases
  • Medical Personnel
  • Neoplasms
  • Proteins
  • Stem Cells

Readers

  • Neuroscience
  • Oncology
  • Theoretical Analysis.

Technology Areas

  • Biotechnology