Investigating the Multifaceted Impact of HIF-1 during Prostate Cancer and Its Potential Value as a Therapeutic Target
Abstract
Successful approaches to cancer immunotherapy require an understanding of the immune components in the microenvironment that enhance or inhibit tumor development and growth. Evidence is mounting that distinct T cell subsets contribute in positive or negative ways to these processes. An emerging area of interest relates to mechanisms by which sensing of metabolic cues regulates T cell fate and the character of the immune response. Our recent research suggested that an important metabolic regulator, hypoxia-inducible factor (HIF) -1, is a critical regulator of the balance between regulatory Tcells (Treg) and Th17 cells, both of which play a role in inflammatory carcinogenesis and tumor immunity. These findings suggest that HIF-1 is likely to play an important role in cancer potentially through boosting tumor promoting T cells (Th17).Thus, pharmacologic inhibition of HIF-1 in combination with therapies that target regulatory T cells may inhibit the two T cell types capable of promoting tumors or protecting them from eradication by the immune system. This project explores the efficacy by targeting the HIF-1 and Tregs in mouse cancer model. These experiments should provide new insights into the role of regulatory T cells and Th17 cells in cancer, and help us to design combination immunotherapy strategies that will be more successful in treating patients.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2016
- Accession Number
- AD1030528
Entities
People
- Fan Pan
Organizations
- Johns Hopkins University