Multifunctional PSCA Antibody Fragments for PET and Optical Prostate Cancer Imaging
Abstract
Imaging remains a major unmet need in the management of prostate cancer. We are developing imaging probes based on engineered antibodies that recognize PSCA (prostate stem cell antigen), a cell surface protein highly expressed in prostate cancer. These engineered antibody fragments (cys-mini bodies and cys-diabodies) can be labeled with radioisotopes for noninvasive PET imaging for use at multiple points in the prostate cancer treatment continuum, including staging at diagnosis, monitoring treatment, and re-staging at various points during management. Engineered fragments can also be labeled with fluorescent dyes for visual guidance in an intraoperative setting to ensure complete resection with negative margins. In this project, dually-labeled PSCA imaging agents are being developed that can be used for pre- and intra-operative detection of prostate cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2016
- Accession Number
- AD1030606
Entities
People
- Robert E. Reiter
Organizations
- University of California