Macrophage Efferocytosis and Prostate Cancer Bone Metastasis

Abstract

Findings from this reporting period identify macrophages and efferocytosis as a key mediator of prostate cancer tumor growth. Specifically, phagocytic macrophages and efferocytosis were found to be upregulated in the blood of patients with metastatic prostate cancer. Moreover, inhibiting phagocytic macrophages with the chemotherapeutic trabected in reduced efferocytosis and prostate cancer tumor size in murine models. In addition, trabected in inhibition of macrophages significantly altered macrophages and efferocytosis in the bone microenvironment a common site of prostate cancer metastasis. Furthermore, trabected in treatment was found to significantly reduce bone mass and alter bone remodeling.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2016
Accession Number
AD1030625

Entities

People

  • Benjamin P. Sinder

Organizations

  • University of Michigan

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cell Physiological Processes
  • Cells
  • Department Of Defense
  • Diseases And Disorders
  • Gene Expression
  • Immune System
  • Inhibition
  • Inhibitors
  • Lymphocytes
  • Macrophages
  • Medical Personnel
  • Metastasis
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • T Lymphocytes

Fields of Study

  • Biology
  • Medicine

Readers

  • Aerospace Propulsion Engineering.
  • Oncology (Cancer Research).