A Molecular Framework for Understanding DCIS

Abstract

This project centers on creating a molecular framework of DCIS (ductal carcinoma in situ). DCIS is considered to be the precursor to Invasive Ductal Carcinoma (IDC), the most common form of breast cancer. IDC accounts for 80 of all breast cancers, predominantly affecting women aged 55 and older; however, at least a third of women with IDC are diagnosed before they reach55. Not all patients with DCIS will develop IDC however, we are looking for ways to better predict those patients that need lifesaving treatment, and separate these from those patients who are less at risk. So far we have over 3000 lesions dissected from 70 freshly frozen patient biopsies, these have been annotated by our pathologist and prepared to be taken on for sequencing. The tissue includes DCIS, IDC, stroma adjacent to DCIS/IDC and normal tissue. We have initiated the RNA sequencing from these samples and also the DNA sequencing

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2016
Accession Number
AD1031102

Entities

People

  • Clare Rebbeck
  • Gregory Hannon

Organizations

  • University of Cambridge

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Breast Cancer
  • Carcinoma
  • Data Analysis
  • Data Processing
  • Department Of Defense
  • Diseases And Disorders
  • Dna Sequence Analysis
  • Epithelium
  • Genetic Structures
  • Medical Personnel
  • Neoplasms
  • Personal Information Managers
  • Physicians
  • Precursors
  • Professional Development

Fields of Study

  • Medicine

Readers

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