Acceleration of Regeneration of Large-Gap Peripheral Nerve Injuries Using Acellular Nerve Allografts plus amniotic Fluid Derived Stem Cells (AFS)

Abstract

Major accomplishments this year include the use of AFS seeded a cellular Nerve Allografts (ANA) to repair critical size nerve defects (1.5cm) in rats. Functional recovery was monitored longitudinally using digital video gait analysis as wells as electrophysiologic and histologic outcomes. The results demonstrated that the AFS seeded ANA used for nerve repair resulted in an improved functional outcome for the rats compared to ANA alone and were equivalent to those repaired using nerve autograph, the current gold standard for tension-free repair of transected peripheral nerves. Axon counts and neuromuscular junction morphology were equivalent between the AFS seeded ANA.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2016
Accession Number
AD1031113

Entities

People

  • Li Zhongyu
  • Thomas L. Smith

Organizations

  • Wake Forest University

Tags

DTIC Thesaurus Topics

  • Allografts
  • Amniotic Fluid
  • Anatomy
  • Biological Sciences
  • Biomedical Research
  • Cells
  • Digital Video
  • Maryland
  • Peripheral Nervous System
  • Recovery
  • Standards
  • Stem Cells
  • Universities

Fields of Study

  • Medicine

Readers

  • Allergy and Immunology.
  • Neuroscience

Technology Areas

  • Biotechnology