Discovery and Synthesis of GS-5734, a Phosphoramidate Prodrug of a Pyrrolo[2,1 f][triazin-4-amino] Adenine C-Nucleoside for the Treatment of Ebola and Emerging Viruses
Abstract
The recent Ebola outbreak in West Africa was the largest recorded in history with over 28,000 cases confirmed in Guinea, Liberia, and Sierra Leone resulting in >11,000 deaths including >500 healthcare workers. This international crisis demonstrated the urgent need for a safe, effective and readily available treatment of Ebola infection. Multiple promising small molecule drugs and biologics were rapidly pushed into clinical trials, including several nucleoside based therapeutics.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 26, 2017
- Accession Number
- AD1031184
Entities
People
- Adrian S. Ray
- Arnold L. Rheingold
- Bruce Ross
- Dustin Siegel
- Edward Doerffler
- Ernest Carra
- Gary Lee
- Hon C. Hui
- Jason Perry
- John Knox
- Joy Y. Feng
- Kirsten M. Stray
- Kwon Chun
- Lijun Zhang
- Lydia Wolfe
- Michael K. Lo
- Michael O. Clarke
- Michel Perron
- Ona Baraskaus
- Queenie Wang
- Richard L Mackman
- Robert Jordan
- Robert Strickley
- Roy Bannister
- Sean Neville
- Sina Bavari
- Swami Swaminathan
- Tomas Cihlar
- Travis K. Warren
- Veronica Soloveva
- Willard Lew
- William A. Lee
- Yili Xu
Organizations
- United States Army Medical Research Institute of Infectious Diseases