Reinnervation of Paralyzed Muscle by Nerve Muscle Endplate Band Grafting

Abstract

Our previous studies showed that NMEG-NMZ reinnervation technique resulted in functional recovery (82 of the control) of the target muscle. In order to promote the efficacy of NME-NMZ, we investigated the effects of focal administration of exogenous neurotrophic factors (ENF) and intra-operative nerve electrical stimulation (ES) on the outcomes of NMEG-NMZ (NN) technique. At 3 months after treatment, we analyzed the muscle force, muscle mass, myofiber morphology, regenerated axons, and endplate reinnervation. The results showed that NN/ENF and NN/ES cotreatments resulted in more optimal functional recovery (91 and 90 of the control, respectively) as compared with NMEG-NMZ surgery alone (82 ). Histological and immunohistochemical studies showed that NN/ENF treated muscles exhibited excellent muscle mass recovery (92 of the control), abundant regenerated axons (84 of the control), and a high percentage (86 ) of reinnervated motor endplates. Our findings suggest that NN/ENF or NN/ES improves the outcomes of NMEG-NMZ reinnervation technique.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2016
Accession Number
AD1031280

Entities

People

  • Jingming Chen
  • Liancai Mu
  • Stanislaw Sobotka

Organizations

  • Hackensack University Medical Center

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Acquisition
  • Biomedical Research
  • Bone And Bones
  • Chemistry
  • Data Analysis
  • Department Of Defense
  • Measurement
  • Medical Personnel
  • Muscle Fibers
  • Peripheral Nervous System
  • Professional Development
  • Recovery
  • Standards
  • Students
  • Surgery
  • United States

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