Development of Dietary Polyphenol Preparations for Treating Veterans with Gulf War Illness

Abstract

There are no treatments for Gulf War Illness (GWI) and there is an urgent need to develop novel interventions either to resolve underlying GWI mechanisms, or to alleviate major GWI clinical complications, particularly chronic fatigue, cognitive difficulties, muscle pain, as well as mood disturbances and sleep problems. Recent evidence from our group and from others revealed that certain dietary flavonoids may promote cognitive function and/or alleviate chronic fatigue. We hypothesized that dietary supplementation with a Flavonoid Rich Preparation (FRP), a combination of Concord Grape Juice (CGJ) and Grape Seed Polyphenolic Extract (GSPE) may help alleviate clinical complications of GWI, particularly chronic fatigue and/or cognitive dysfunction. We propose to test the feasibility of dietary supplementation with FRP in Veterans with GWI, and to gather evidence supporting the efficacy of FRP in alleviating GWI-associated cognitive deficits and chronic fatigue.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2016
Accession Number
AD1031284

Entities

People

  • Giulio Maria Pasinetti

Organizations

  • Icahn School of Medicine at Mount Sinai

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Clinical Trials
  • Department Of Defense
  • Department Of Veterans Affairs
  • Electronic Mail
  • Governments
  • Health Care
  • Health Services
  • Institutional Review Board
  • Law
  • Medical Personnel
  • New Jersey
  • New York
  • Persian Gulf Syndrome
  • Resource Management
  • Side Effects

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.