Drosophila as a Screening Platform for Novel Lung Cancer Therapeutics

Abstract

The research in this grant is designed to explore the effects of genetic and genomic complexity in lung cancer progression and response to therapeutics. Using Drosophila, we are establishing a set of personalized fly lines, each which represents a separate patient. In this Progress Report, I discuss our initial studies in building these lines. In addition, I discuss our results with screening a library of 1200 FDA approved drugs. We provide evidence that a two drug cocktail, trametinib plus fluvastatin, synergize to improve efficacy and minimize toxicity in fly and human cell line models.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2016
Accession Number
AD1031293

Entities

People

  • Ross Cagan

Organizations

  • Icahn School of Medicine at Mount Sinai

Tags

DTIC Thesaurus Topics

  • Animal Structures
  • Animals
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Diptera
  • Diseases And Disorders
  • Enzyme Inhibitors
  • Lung Cancer
  • Lymphatic Diseases
  • Medical Personnel
  • Morphogenesis
  • Neoplasms
  • Statins
  • Therapy
  • Toxicity

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Oncology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech