Genetic Modeling of Radiation Injury in Prostate Cancer Patients Treated with Radiotherapy

Abstract

From the completed analyses performed during the first year of the project, we have identified eleven SNPs that show an association with two-year toxicity following prostate cancer radiotherapy. Three of these single nucleotide polymorphisms (SNPs) meet the stringent threshold for genome-wide significance (meta-p-value < 5x10-8), and eight others approached genome-wide significance. For the three genome-wide significant SNPs, we found that the direction of the effect was consistent across all studies for which data were available.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2016
Accession Number
AD1031443

Entities

People

  • Barry S. Rosenstein
  • Harry Ostrer

Organizations

  • Icahn School of Medicine at Mount Sinai

Tags

Communities of Interest

  • Energy and Power Technologies
  • Human Systems

DTIC Thesaurus Topics

  • Data Management
  • Health Services
  • Information Science
  • Medical Personnel
  • Neoplasms
  • Nucleotides
  • Predictive Modeling
  • Prostate
  • Prostate Cancer
  • Radiation Oncology
  • Radiotherapy
  • Risk
  • Statistical Analysis
  • Supervised Machine Learning
  • Supervision
  • Therapy
  • Toxicity

Fields of Study

  • Biology
  • Physics

Readers

  • Molecular Genetics
  • Technical Research and Report Writing.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology