Mitochondrial-Based Treatments that Prevent Post-Traumatic Osteoarthritis in a Translational Large Animal Intraarticular Fracture Survival Model

Abstract

The results of Specific Aims 1 and 2 in the rabbit model strongly supported choosing amobarbital and NAC for testing in the porcine intra-articular fracture model, which was proposed for Specific Aim 3. Data from Specific Aim 3 showed that acute treatment with amobarbital or NAC had significantly delayed the onset of arthritis in a clinically realistic model of PTOA.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2016
Accession Number
AD1031776

Entities

People

  • James A. Martin

Organizations

  • University of Iowa

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Arthritis
  • Bone Fractures
  • Cells
  • Chemistry
  • Data Analysis
  • Department Of Defense
  • Diseases And Disorders
  • Inhibition
  • Inhibitors
  • Intellectual Property
  • Metabolism
  • Orthopedic Surgical Procedures
  • Oxidative Stress
  • Patents
  • Surgery
  • Survival

Fields of Study

  • Chemistry
  • Medicine

Readers

  • Neurotrauma and Rehabilitation Medicine.