Optimization of Soft Tissue Management, Spacer Design, and Grafting Strategies for Large Segmental Bone Defects using the Chronic Caprine Tibial Defect Model

Abstract

This proposal addresses the treatment of segmental bone defects and methods that can be used to manipulate the Masquelet induced membrane to create a graft bed that optimizes bone regeneration. The effect of surgical management of the IM demonstrated a significant benefit of scraping to remove the inner layer of the IM (p=0.041).In contrast, modifying the texture on the PMMA spacer to double the surface area of the IM did not result in improved bone regeneration. This finding can be immediately translated into clinical practice. This study high lights the fact that the Chronic Caprine Tibial Defect Model is sufficiently sensitive to detect variations and represents a suitable clinically relevant animal model for testing new therapies for bone regeneration.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2016
Accession Number
AD1031940

Entities

People

  • G. E. Pluhar

Organizations

  • University of Minnesota

Tags

Communities of Interest

  • Energy and Power Technologies
  • Ground and Sea Platforms
  • Human Systems
  • Weapons Technologies

DTIC Thesaurus Topics

  • Adipose Tissue
  • Bone And Bones
  • Bone Regeneration
  • Cartilage
  • Casualties
  • Cells
  • Computational Science
  • Connective Tissue
  • Data Mining
  • Information Science
  • Medical Personnel
  • Membranes
  • Osteogenesis
  • Peptide Growth Factors
  • Predictive Modeling
  • Soft Tissues
  • Statistical Analysis

Readers

  • Nanofabrication and Microfabrication.
  • Trauma Surgery or Emergency Medicine.