Optimizing Soft Tissue Management and Spacer Design in Segmental Bone Defects

Abstract

This proposal addresses the treatment of segmental bone defects and methods that can be used to manipulate the Masquelet induced membrane to create a graft bed that optimizes bone regeneration. The effect of surgical management of the IM demonstrated a significant benefit of scraping to remove the inner layer of the IM (p=0.041). In contrast, modifying the texture on the PMMA spacer to double the surface area of the IM did not result in improved bone regeneration. This finding can be immediately translated into clinical practice. This study also highlights that the Chronic Caprine Tibial Defect Model is sufficiently sensitive to detect variations and represents a particularly well suitable relevant large animal model to advance the field of clinical bone regeneration using cellular therapies, and optimization of clinically relevant methods for harvest and processing of CTP sources to enhance the concentration and prevalence CTPs in the site of bone regeneration.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2016
Accession Number
AD1032199

Entities

People

  • George F. Muschler

Tags

Communities of Interest

  • Air Platforms
  • Energy and Power Technologies
  • Ground and Sea Platforms
  • Weapons Technologies

DTIC Thesaurus Topics

  • Bone Regeneration
  • Cartilage
  • Cells
  • Computational Science
  • Connective Tissue
  • Data Analysis
  • Data Mining
  • Information Science
  • Medical Personnel
  • Membranes
  • Military Medicine
  • Osteogenesis
  • Peptide Growth Factors
  • Predictive Modeling
  • Statistical Analysis
  • Three Dimensional
  • Wounds And Injuries

Readers

  • Oncology
  • Trauma Surgery or Emergency Medicine.