Targeting Signaling to YAP for the Therapy of NF2

Abstract

The goals of this project are to utilize our new knowledge of the mechanism by which loss of Merlin induces tumorigenesis to identify small molecule compounds that block YAP/TEAD-dependent transcription by acting at any step of our newly identified pathway, and to test the preclinical efficacy of lead compounds in xenograft models of NF2. During this grant, we have generated NF2 mutant cell lines expressing two different types of YAP reporters and tested their suitability for high throughput screening.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2016
Accession Number
AD1032204

Entities

People

  • Filippo G. Giancotti

Tags

DTIC Thesaurus Topics

  • Biology
  • Biomedical Research
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Compounds
  • Confocal Microscopy
  • Intercellular Junctions
  • Lead Compounds
  • Medical Personnel
  • Molecular Biology
  • Molecules
  • Neoplasms
  • Small Molecules
  • Therapy
  • Throughput

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  • Neurological Diseases/Conditions/Disorders