A Brain-Machine-Brain Interface for Rewiring of Cortical Circuitry after Traumatic Brain Injury

Abstract

A small, lightweight microsystem has been developed for activity-dependent stimulation (ADS) and successfully tested for functionality in both anesthetized and ambulatory rats. Furthermore, in semi-chronic experiments in rats with traumatic brain injury (TBI) using this microsystem, an unprecedented, potent effect of ADS on motor performance has been demonstrated, as compared to control rats (injured but no microsystem) and open-loop stimulation (OLS) rats. Specifically, OLS does result in some recovery after injury, but ADS is significantly more efficacious, resulting in recovery to normal ranges of performance within 2 weeks after injury. Prior to implementation in clinical trials, translation to non-human primates (NHPs) is critical.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2015
Accession Number
AD1032844

Entities

People

  • Pedram Mohseni
  • Randolph J Nudo

Organizations

  • University of Kansas Medical Center

Tags

Communities of Interest

  • Advanced Electronics
  • Energy and Power Technologies
  • Engineered Resilient Systems
  • Ground and Sea Platforms

DTIC Thesaurus Topics

  • Brain
  • Brain Injuries
  • Control Systems
  • Electrical Engineering
  • Health Services
  • Medical Personnel
  • Neurosciences
  • Parkinson'S Disease
  • Prostheses And Implants
  • Prosthetics

Fields of Study

  • Biology

Readers

  • Neuroscience
  • Neurotrauma and Rehabilitation Medicine.