Echo-Planar Imaging-Based, J-Resolved Spectroscopic Imaging for Improved Metabolite Detection in Prostate Cancer
Abstract
Purpose: 1) To implement an echo-planar imaging (EPI)-based 2D J-resolved spectroscopy on a 3T MRI/MRS scanner; 2) To evaluate the multi-voxel 2D J-resolved echo-planar spectroscopic imaging (EP-JRESI) in malignant prostate cancer (PCa)patients, benign prostatic hyperplasia (BPH) patients and healthy prostates. 3) To develop and further optimize the ProFit algorithm to post-process the multi-dimensional MRS data from different prostate pathologies. Scope: Improved cancer detection (specificity) in differentiating malignant from benign prostate cancer can be achieved using a novel four-dimensional (4D) EP-JRESI. Improved spectroscopic imaging techniques will enable unambiguous detection of metabolites and the lipids in situ, which could potentially complement existing diagnostic modalities commonly used in PCa. Progress and Major Findings: After successful implementation of the 4D EP-JRESI sequence on a 3T MRI scanner, the 4D EP-JRESI data were recorded in 47 PCa patients and 9 healthy males during the funded years. The sequence has been compiled using Siemens different platform compilers and the sequence is currently shared with other sites. Seven peer-reviewed manuscripts, 13 conference abstracts and two book chapters have been published so far with one more manuscript in preparation. Our abstract to the 2017 ISMRM meeting has been invited for oral as well as ePoster presentations.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2016
- Accession Number
- AD1032849
Entities
People
- Michael A Thomas
Organizations
- University of California