Microenvironments and Signaling Pathways Regulating Early Dissemination, Dormancy, and Metastasis
Abstract
We devoted effort to both aims, to optimize methods and publish the first phase of efforts. SA1 is to understand the intrinsic mechanisms of dissemination by early-progressed cancer cells and how the microenvironment in these primary sites named P-TMEM (Primary Tumor Microenvironment of Metastases) contribute to early dissemination. We now have new data suggesting that a signature of early dissemination markers consisting on HER2HI/p-ATF2LO/E-cadhLO could identify motile early-progressed tumor cells and predict for dissemination. We further show that mammary tissue macrophages and HER2HI/p-ATF2LO/E-cadhLO tumor cells cooperate to disseminate early.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2016
- Accession Number
- AD1033114
Entities
People
- John Condeelis
- Julio Aguirre-Ghiso
Organizations
- Albert Einstein College of Medicine