Inhibition of Retinoblastoma Protein Inactivation

Abstract

The objective of this project is to discover and characterize molecules that inhibit breast cancer cell proliferation by maintaining activity of the retinoblastoma protein (Rb). Rb is inactivated to drive proliferation in normal and cancer cells by phosphorylation, which dissociates the E2F transcription factor from Rb. Our goal is to find and characterize molecules that stabilize the complex between phosphorylated Rb and E2F.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2016
Accession Number
AD1033117

Entities

People

  • Seth M. Rubin

Organizations

  • University of California, Santa Cruz

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cell Physiological Processes
  • Crystallography
  • Crystals
  • Inhibition
  • Lead Compounds
  • Molecules
  • Neoplasms
  • Phosphorylation
  • Protein-Protein Interactions
  • Proteins
  • Retinal Diseases
  • Small Molecules
  • Transcription Factors
  • X Rays
  • X-Ray Crystallography
  • X-Ray Diffraction

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics