Primary Blast Injury Criteria for Animal/Human TBI Models using Field Validated Shock Tubes

Abstract

Injury severity in blast induced Traumatic Brain Injury (bTBI) increases with blast overpressure (BOP) and impulse in dose-dependent manner. Pure primary blast waves were simulated in compressed gas shock-tubes in discrete increments. We evaluated 24 hour survival of rats in 0-450 kPa (0-800 Pas impulse) range at 10 discrete levels (60, 100, 130, 160, 190, 230, 250, 290, 350 and 420 kPa) and determined the mortality rate as a non-linear function of BOP. Using logistic regression model, predicted mortality rate (PMR) function was calculated, and used to establish TBI severities. We determined a BOP of 145 kPa as upper mild TBI threshold (5 % PMR). Also we determined 146-220 kPa and 221-290 kPa levels as moderate and severe TBI based on 35%, and 70% PMR, respectively, while BOP above 290 kPa is lethal.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2016
Accession Number
AD1033280

Entities

People

  • Maciej Skotak
  • Namas Chandra

Organizations

  • New Jersey Institute of Technology

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Arteries
  • Biomedical Research
  • Blast Injuries
  • Blast Waves
  • Blood
  • Brain Injuries
  • Cardiovascular Physiological Phenomena
  • Data Analysis
  • Free Radicals
  • Heart Rate
  • Medical Personnel
  • Overpressure
  • Pressure Measurement
  • Shock Tubes
  • Students
  • Wave Propagation
  • Wounds And Injuries

Readers

  • Explosive Engineering.
  • Neurotrauma and Rehabilitation Medicine.
  • Statistical inference.