microRNA in Cerebral Spinal Fluid as Biomarkers of Alzheimer's Disease Risk After Brain Injury

Abstract

A history of TBI increases the odds of developing AD by 2.5 times in the general population, and 4-6 times for military veterans. Although significant associations between mTBI and risk of AD have been observed, the precise mechanism by which TBI might lead to AD and/or AD-related symptoms are not yet understood. Histologically, AD is characterized by amyloid- and neurofibrillary protein aggregates, suggesting a loss of protein processing is a key feature of AD. MiRNAs are small non-coding RNA that regulate mRNA transcription, and may be a significant cause of protein dysregulation.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2016
Accession Number
AD1033283

Entities

People

  • Joseph Quinn
  • Theresa A. Lusardi

Organizations

  • Oregon Health & Science University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Alzheimer Disease
  • Biological Markers
  • Biomedical Information Systems
  • Biomedical Research
  • Blast Injuries
  • Brain Diseases
  • Brain Injuries
  • Central Nervous System Diseases
  • Classification
  • Computational Biology
  • Diseases And Disorders
  • Institutional Review Board
  • Medical Personnel
  • Patent Applications
  • Professional Development
  • Technology Transfer

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.