Minimally Invasive Radiation Biodosimetry and Evaluation of Organ Responses
Abstract
The study during the reporting period has used blood samples from leukemia patients who received therapeutic radiation for discovery of biomarkers. This could be used for exposure estimation in soldiers and emergency responders involved in nuclear war. The method for discovery and validation of biomarkers was optimized using samples collected from patients enrolled in two clinical trials. The utility of selected biomarkers identified from our earlier animal models has been validated and identified as responders in human samples. Biomarkers identified and/or validated include miRNA-150 and miRNA-574-5p that alters as a function of dose and time. The levels of circulating miR-150 was found reduced in a dose and time dependent manner, while that of miRNA-574 was found increasing after radiation in dose and time dependent manner. Additional putative biomarkers exhibiting dose-time response have been identified, which need validation. The findings will likely have significant impact on Nations Radiation Biodosimetry Program and the preparedness for emergency responses in radiological events.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2016
- Accession Number
- AD1033397
Entities
People
- Naduparambil K Jacob
Organizations
- Ohio State University