Inflammation Modulatory Protein TSG-6 for Chemical Injuries to the Cornea

Abstract

During this study period we initiated testing to evaluate the effectiveness TSG-6 applied intravenously (IV) after corneal alkali burn in the rat model, and completed the setup of equipment and facilities for TSG-6 production for intravenous studies at the Central Texas Veterans Health Care System Research building, after the migration of the Texas A and M Institute of Regenerative Medicine from Temple, Texas to College Station, Texas. We found that lower dose IV TSG-6 applied singly immediately after injury did not provide a statistically significant benefit to the cornea after alkali injury as evaluated by corneal clarity and by biochemical markers of inflammation. Experiments to test the effectiveness of higher dose IV TSG-6, with and without topical TSG-6, are underway.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2016
Accession Number
AD1033525

Entities

People

  • Samuel Fulcher

Tags

DTIC Thesaurus Topics

  • Cells
  • Corneal Diseases
  • Eye
  • Eye Diseases
  • Filter Paper
  • Health
  • Health Care
  • Health Services
  • Inflammation
  • Ophthalmology
  • Production
  • Regenerative Medicine
  • Research Facilities
  • Veterans Health

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