Towards a Molecular Understanding of Noise-Induced Hearing Loss

Abstract

The purpose of this project is to generate the cell type-specific molecular blueprint of changes in gene expression following different types of noise exposure and their treatments, in the inner ear. To this end, we have (a) Established the hair cell and supporting cell-specific translatome of adult mouse inner ears; (b) Established the molecular changes induced by PTS-resulting noise exposure in hair cells, support cells and whole inner ears, 6 and 24 hours after noise exposure; (c) Collected and processed most of the tissue for TTS-resulting noise exposure. In addition, we have two manuscripts in preparation describing findings that arose as sub-projects of the main proposal.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2016
Accession Number
AD1033527

Entities

People

  • Ronna Hertzano

Organizations

  • University of Maryland School of Medicine

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Animals
  • Calibration
  • Data Analysis
  • Department Of Defense
  • Ear
  • Gene Expression
  • Hearing Disorders
  • Hearing Loss
  • Intellectual Property
  • Measurement
  • Medical Personnel
  • Organ Of Corti
  • Otorhinolaryngologic Diseases
  • Otorhinolaryngology
  • Ototoxicity
  • Training

Readers

  • Auditory Neuroscience/Auditory Physiology.
  • Molecular and Cellular Biology
  • Technical Research and Report Writing.