New Strategies in Targeted Interventions for Posttraumatic Osteoarthritis (PT-OA)
Abstract
The subject of this project is Post-Traumatic Osteoarthritis (PT-OA), which is a form of Osteoarthritis (OA) with particularly rapid onset that leads to painful and disabling disease in otherwise healthy and relatively young adults,including military service members who have sustained traumatic joint injuries. This project will provide mechanistic proof-of-concept for our hypothesis that stimulating anabolic cartilage responses, and inhibiting catabolic ones, will slow the onset or progression of PT-OA following traumatic joint injury. The project will investigate the mechanistic involvement of EGFR growth factor signaling in mediating anabolic and catabolic responses in articular cartilage, and will develop strategies for modulating EGFR signaling in the joint as a means to control EGFR-mediated anabolic and catabolic responses. The impact of the project is to provide proof-of-concept support for a new mechanistically-based therapeutic intervention for PT-OA.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2016
- Accession Number
- AD1033814
Entities
People
- Caroline N. Dealy
Organizations
- University of Connecticut Health Center