Combating Posttraumatic Osteoarthritis via Enhanced Intra-Articular Recruitment of Stem Cells and Targeting Delivery of a Chondrogenic Agent

Abstract

The focus of this project is to utilize an in situ regenerative medicine-based approach to mitigate the onset and progression of post-traumatic osteoarthritis (PTOA) following rupture of the anterior cruciate ligament (ACL). Though a preliminary finding, our group has validated that rupture of the anterior cruciate ligament (ACL) in the knee results in a significant increase in the number of marrow-derived mesenchymal stem cell circulating in peripheral blood. We have also determined that these cells in circulation migrate preferentially to the injured knee and engraft within the synovium. This potentially validates our hypothesis that additional molecular signals (chemokines) are needed to increase the recruitment of stem cells inside the injured joint to mitigate the onset and progression of post-traumatic osteoarthritis. Work is no underway using chimeric animals with marrow cells that express green fluorescent protein.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2016
Accession Number
AD1033867

Entities

People

  • Kevin C Baker

Tags

DTIC Thesaurus Topics

  • Arthritis
  • Bone Marrow
  • Bone Marrow Cells
  • Cartilage
  • Cells
  • Data Analysis
  • Health Services
  • Ligaments
  • Medical Personnel
  • Regenerative Medicine
  • Stem Cells
  • Surgery
  • Therapy

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Neurotrauma and Rehabilitation Medicine.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech