Enhancing Immune Checkpoint Inhibitor Therapy In Kidney Cancer

Abstract

The purpose of this research is to test therapeutic strategies to make immune checkpoint inhibition more effective in an animal model of kidney cancer. Our plan is to combine focally ablative techniques such as radiation or cry therapy with PD1 immune checkpoint inhibition and assess the abscopal effect, i.e. the growth of tumors at a distant, untreated site. Additionally, we will test the effect of TLR agonist administration in this model and look at combination with focally ablative techniques.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2016
Accession Number
AD1033914

Entities

People

  • Hans Hammers

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Biomedical Research
  • Culture Techniques
  • Department Of Defense
  • Electronic Mail
  • Employment
  • Information Operations
  • Inhibition
  • Inhibitors
  • Kidney Cancer
  • Maryland
  • Medical Personnel
  • Personnel Management
  • Radiation
  • Therapy

Fields of Study

  • Biology

Readers

  • Oncology