Ex Vivo Machine Perfusion in VCA with a Novel Oxygen Carrier System to Enhance Graft Preservation and Immunologic Outcomes

Abstract

The objective of this proposal is to establish the graft preservation and immunomodulatory effects of our MP-BMPS/HBOC system in a pre-clinical large animal CTA model. We will specifically address the following specific aims in a porcine vascularized musculo-adipo-cutaneous flap model: Aim 1: Does MP-BMPS/HBOC allow prolongation of CIT without significant cellular damage to the allograft? Aim 2: Does the MP-BMPS/HBOC minimize the effects and incidence of ischemia-reperfusion injury at revascularization? Aim 3: What is the effect of MP-BMPS/HBOC on the immune profile of various flap tissues after transplantation?

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2016
Accession Number
AD1033982

Entities

People

  • Paulo Fontes

Organizations

  • University of Pittsburgh

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Allografts
  • Blood
  • Cardiovascular Diseases
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Health Services
  • Medical Personnel
  • Muscle Cells
  • Proteins
  • Skeletal Muscle
  • Surgery
  • Transplants
  • Vascular Diseases

Fields of Study

  • Medicine

Readers

  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Biotechnology