Local Tacrolimus (FK506) Delivery for Prevention of Acute Rejection in the Nonhuman Primate Delayed Mixed Chimerism Vascularized Composite Allograft Tolerance Induction Protocol

Abstract

The focus for Year 1 was to develop a polymeric local delivery system (PLDS) for tacrolimus (FK506), and characterize in vitro. The work included selecting and characterizing the polymer for the PLDS, optimizing a fabrication method, and developing characterization methods to test the pharmacokinetics after drug loading. To this end, the team synthesized and characterized a batch of the chosen tyrosine-derived polymer formulation, E1218(1k), and moved forward in finalizing the fabrication method for the PLDS. Method development for in-depth pharmacokinetic studies is currently underway, and preclinical animal studies are currently being planned for testing the PLDS in a small animal model as well as a non-human primate model.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2016
Accession Number
AD1034081

Entities

People

  • Curtis L. Cetrulo, Jr

Organizations

  • Massachusetts General Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Allografts
  • Casualties
  • Chimerism
  • Composite Materials
  • Compression Molding
  • Ear
  • Fabrication
  • Health Services
  • Liquid Chromatography
  • Materials Processing
  • Medical Personnel
  • Melting Point
  • Pharmacokinetics
  • Polymers
  • Rejection
  • Transplants
  • Upper Extremity

Readers

  • Clinical Trial Research.
  • Nanocomposite Materials Science
  • Neuroscience