Localizing and Assessing Amputee Pain with Intense Focused Ultrasound

Abstract

Here we propose exploratory studies to stimulate subcutaneous pain generators in patients within residual limbs using research image-guided intense focused ultrasound (ig-iFU) system. Out targets for iFU stimulation include neuromas, intact nerves, TMR (targeted muscle reinnervation) sites, and patient-identified 'sensitive areas'. Successful application of iFU to deep, potentially painful tissue should allow us to locate that tissue and compare their relative sensitivity to external stimulation. This would be consistent with our preliminary human data. Also, our rat studies suggest it plausible that painful tissue in humans would require less ultrasound to generate a sensation than surrounding tissue. We specifically anticipate that we will show that TMR sites are less sensitive than neuromas. This and our questionnaire studies will support the view that TMR surgery may reduce amputee pain relative to standard amputation surgery.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2016
Accession Number
AD1034085

Entities

People

  • Pierre D. Mourad

Organizations

  • University of Washington

Tags

DTIC Thesaurus Topics

  • Amputees
  • Biological Sciences
  • Institutional Review Board
  • Lower Limb Amputations
  • Medical Personnel
  • Pain
  • Pain Management
  • Peripheral Nervous System
  • Residual Limbs
  • Sciatic Nerve
  • Sensory Receptor Cells
  • Surgery
  • Surgical Amputations
  • Vascular Diseases

Fields of Study

  • Medicine

Readers

  • Medical Imaging.
  • Neuroscience
  • Neurotrauma and Rehabilitation Medicine.