Comprehensive Genetic Characterization of Intraprostatic Chronic Inflammation and Prostate Cancer in African American Men
Abstract
African-Americans (AA) have a higher incidence of prostate cancer (PCa) and higher mortality. Stromal and epithelial inflammatory processes have a fundamental role in carcinogenesis and may predict PCa clinical progression. Discovery of novel variants as well as re-discovery of known variants deliver new opportunities for therapeutic advances such as new drug targets and personalized therapy. We hypothesize next-generation whole genome sequencing, paired with new methodologies of intratumoral phylogenetic analyses, will yield pivotal information in elucidating the key genes involved evolution of PCa from precursor inflammatory lesions in AA men. During this research period, extensive translational research training has been completed including both clinical training as well as training in bioinformatics. The most significant outcome of the present study has been the assemblage of a robust database of clinical annotation and follow-up for early stage prostate cancer patients treated at Tulane University Medical Center. This database combined with genetic data produced by this study may empower patients and doctors to make personalized treatment decisions and ultimately improve treatment outcomes. Similarly, as product of training, research database and ongoing genetic analyses, the PI has had the opportunity to collaborate on numerous publications and conference presentations.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2016
- Accession Number
- AD1034113
Entities
People
- Elisa M Ledet