Availability of Acute and/or Subacute Toxicokinetic Data for Select Compounds for the Rat and Physiologically Based Pharmacokinetic (PBPK) Models for Rats and Humans for Those Compounds

Abstract

US Army Center for Environmental Health Research (USACEHR) has expressed a need for support for the physiologically based pharmacokinetic (PBPK) modeling efforts. Specifically, information has been requested regarding the availability of acute and/or subacute toxicokinetic data and PBPK models for arsenic, cadmium, chromium, cobalt, lead, nickel, allyl alcohol, bromobenzene, and carbon tetrachloride, in the rat. As the interest in these models pertains to data development in the rat and extrapolation to humans, BPK models for humans were also of interest. Short-term toxicokinetic data in the rat were identified for all compounds of interest. Toxicokinetic/biokinetic models for at least one species (rat or human) exist for all compounds of interest except nickel and bromobenzene.

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Document Details

Document Type
Technical Report
Publication Date
May 04, 2017
Accession Number
AD1034952

Entities

People

  • Lisa M. Sweeney
  • Michelle R. Goodwin

Organizations

  • Naval Medical Research Unit Dayton

Tags

DTIC Thesaurus Topics

  • Alkenes
  • Arsenates
  • Arteries
  • Blood
  • Bodily Secretions
  • Carbon Tetrachloride
  • Chemical Kinetics
  • Chemical Synthesis
  • Chemistry
  • Digestive System Processes
  • Environmental Health
  • Enzyme Kinetics
  • Organic Chemistry
  • Plant Oils
  • Rodents
  • Urogenital System
  • Veins

Readers

  • Aviation Safety Risk Assessment.
  • Organic Chemistry
  • Surface Engineering/Surface Coating Technology.