A Non-Invasive Biomarker for Intracranial Pressure

Abstract

Improvised explosive devices induce head injuries in over 40% of soldiers who survive. Increased intracranial pressure (ICP) frequently occurs in this context; successfully managing ICP improves clinical outcome, but currently requires an invasive, surgical procedure for its assay. A rapid, easy, and non-invasive method to monitor ICP would therefore be extremely useful for managing such injuries. We demonstrated in vitro that safe (as tested in vivo) ultrasound-induced palpation and, separately vibration of brain-tissue phantom correlated with the overpressure on that phantom. We demonstrated in vivo that ultrasound-induced palpation of brain varied with ICP, but not in a statistically significant fashion. In contrast, ultrasound-induced vibration of brain did vary with ICP in a statistically significant way. Improved ICP models should yield improved predictive power.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2011
Accession Number
AD1035013

Entities

People

  • Pierre Mourad

Organizations

  • University of Washington

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acoustic Emissions
  • Amplitude
  • Biomedical Research
  • Blood
  • Blood-Brain Barrier
  • Calcium Compounds
  • Carrier Frequencies
  • Detection
  • Emission
  • Engineers
  • Explosive Devices
  • Frequency
  • Measurement
  • Overpressure
  • Surgery
  • Transducers
  • Waveforms

Fields of Study

  • Medicine

Readers

  • Adaptive Control and Estimation with Uncertainty in Dynamic Systems.
  • Medical Imaging.
  • Neurotrauma and Rehabilitation Medicine.