Operation Brain Trauma Therapy

Abstract

Operation brain trauma therapy (OBTT) is a groundbreaking, rigorous, multicenter pre-clinical drug and biomarker screening consortium for traumatic brain injury (TBI). It is supported by2 closely linked grants from DoD, i.e., WH81XWH-10-1-0623 and OBTT extended studies (WH81XWH-14). As requested, this final report is restricted to work on the parent OBTT grant WH81XWH-10-1-0623. OBTT features testing in rat TBI models at the Univ. of Pittsburgh, the Univ. of Miami, and WRAIR, in a micro pig model at Virginia Commonwealth Univ., and biomarker studies at Banyan Biomarkers, Univ. of Florida, and Messina Univ. This grant supported testing of 8drugs. Screening carried out in >1200 rats included standard outcomes and >5000 biomarker samples. Levetiracetam showed the most benefit (in 2 models). Glibenclamide and amantadine showed model dependent benefit in contusion and penetrating brain injury. The biomarker GFAP performed well. OBTT produced 86 deliverables, including a full issue of J Neurotrauma. The biomarker data were well-received by FDA. OBTT is recognized as a pioneer in the TBI field.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2016
Accession Number
AD1035517

Entities

People

  • Patrick M. Kochanek

Organizations

  • University of Pittsburgh

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anticonvulsants
  • Blood
  • Brain
  • Brain Injuries
  • Cardiovascular Physiological Phenomena
  • Cerebral Edema
  • Chemistry
  • Health Services
  • Neurodegeneration
  • Neurosciences
  • Pharmacies

Fields of Study

  • Medicine

Readers

  • Neurotrauma and Rehabilitation Medicine.
  • Research Science/Academic Research